Pharmaceutical compounding

History of isolator and containment technology: Early containment leading to flexible film isolator
PART 1 Abstract This is the first of five papers that will describe the history and development of containment technology in the field of research, medicine and pharmaceutical applications. The paper commences with the development of containment for various purposes but essentially for experiments to determine if the raising of germ free animals was possible and practical. The paper goes on to describe how the experimental work in the late 1920s led to the development of metal and then flexible film isolators for use in veterinary research, human medicine and surgery. The notable contributions of Philip Trexler, known to everyone as Trex, from the 1930s right through to the 1960s, especially in patient care and treatment, are recorded.
Author: Thorogood, Doug.
Importance of risk assessment for aseptic transfer in pharmaceutical compounding
Aseptic transfer is a critical contamination control issue, carried out over a series of stages. If any stage is performed in an uncontrolled manner then microbial contamination of a product can occur. Contamination risks can arise from a number of sources, including incoming materials, air and personnel. To address these risks appropriate controls include controlled environments, personnel gowning and behaviour, and the use of disinfectants. This article considers the key risks and risk mitigation strategies using a case study of aseptic transfer within a pharmacy unit for the purpose of preparation or compounding of a medicinal drug product.
Author: Sandle, Tim.

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